Team Leader: Toshifumi Nomura,
The 1st Lab has been conducting research on
hereditary diseases, ichthyoses and palmoplantar
keratosis in particular. The happiest news for the lab
last year was Dr. Osamu Mizuno receiving his Ph.D.
Dr. Mizuno collected many case records of patients
with Nagashima-type palmoplantar keratosis and conducted
analyses including those for next-generation
sequencing. He confirmed that the cause of this disease
is mutations in the SERPINB7 gene and that the
disease can be pseudo-dominantly inherited. I’d like
to thank him for his hard work. Dr. Toshinari Miyauchi
started his research as a graduate course student
just after Dr. Mizuno completed his course. I strongly
expect Dr. Miyauchi, who’s an excellent researcher
with plenty of grit, to achieve great results.
Dr. Yuka Oguchi and Mr. Shotaro Suzuki have been working
hard as Ph.D. students. Dr. Oguchi has been steadily
conducting R&D for a readthrough drug. I believe she’ll
be getting results in the near future. Mr. Suzuki has
come very close to identifying a new causative gene
for ichthyoses. A considerable result is expected. Ms.
Mai Takeda, a lab tech who’s achieved a high level of
proficiency in many experiment techniques, has been
supporting the lab. The members of the 1st Lab will
continue our efforts to analyze hereditary keratoses
and elucidate the mechanism of stratum corneum formation.
I’d like to ask the readers for their continued
guidance and for their assistance in referring patients.
Download 'The first laboratory' in the annual report 2015, (, 4 pages total: 399KB)